Lalitha Madhavan, MD, PhD

Associate Professor
Associate Professor, Evelyn F McKnight Brain Institute
Associate Professor, Molecular and Cellular Biology, BIO5 Institute
Associate Professor, Medicine, Neuroscience, Physiological Sciences, Clinical Translational Sciences, Applied BioSciences

Contact:

Life Sciences North, Room #350
1501 N Campbell
Department of Neurology
Tucson, AZ 85724-5044
(520) 626-2330
lmadhavan@email.arizona.edu

Dr Madhavan is an Associate Professor in the Department of Neurology, and directs a research program that broadly centers on Stem Cell Biology and Regenerative Medicine.  The ultimate goal is to use this research to develop rational therapeutic strategies to tackle aging and age-related neurological disorders, such as Alzheimer’s and Parkinson’s Disease.

For more details on Dr. Madhavan's research, please visit her lab website at LMadhavan Lab

 

Education

Degrees: 
MD: Baroda Medical College, Vadodara, India
PhD: Neuroscience, Iowa State University, Ames, IA

Selected Publications

  • Ray S, Corenblum MJ, Anandhan A, Reed A, Ortiz FO, Zhang DD, Barnes CA, and Madhavan L. A role for Nrf2 expression in defining the aging of hippocampal neural stem cells. Cell Transplantation. 2018 Jan 1. PMID: 29871525
  • Teves JMY, Bhargava V, Kirwan KR, Corenblum MJ, Justiniano R, Wondrak GT, Annadurai A, Flores AJ, Schipper DA, Khalpey Z, Sligh JE, Curiel-Lewandrowski C, Sherman S and Madhavan L. Parkinson’s disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function and autophagy. Front. Neurosci. 2018 Jan 12;11:737. PMID: 29379409
  • Corenblum, M. J., Madhavan, L. Small-scale Propagation of Human iPSCs in Serum-free Conditions for Routine Immunocytochemical Characterization. J. Vis. Exp. (120), e55260, doi:10.3791/55260 (2017).  PMID: 28287577
  • Umashankar A, Corenblum MJ, Ray S, Valdez M, Yoshimaru E, Trouard T, and Madhavan L.  Effects of the iron oxide nanoparticle Molday Ion Rhodamine B on the viability and regenerative function of neural stem cells: Relevance to clinical translation. International Journal of Nanomedicine 2016:11 1731–1748. PMID: 27175074
  • Corenblum MJ, Ray S, Remley QW, Long M, Harder B, Zhang DD, Barnes CA, and Madhavan L. Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period.  Aging Cell. 2016 Apr 20. doi: 10.1111/acel.12482. PMID: 27095375
  • Madhavan L, Daley BF, Davidson BL, Boudreau RL, Cole-Strauss A, Lipton JW, Steece-Collier K, and Collier TJ; Sonic hedgehog controls the phenotypic fate and and therapeutic potential of grafted neural stem cells in a model of nigrostriatal degeneration.  PLOSOne. 2015 Sep 4;10(9):e0137136. PMID: 26340267
  • Corenblum MJ,  Flores AJ, Badowski M, Harris DT, and Madhavan L.  Systemic human CD34+ stem cells populate the brain and activate host-based mechanisms to counteract nigrostriatal neurodegeneration. Regen Med. 2015 Aug;10(5):563-77. PMID: 26237701
  • Madhavan L.  Redox-based regulation of neural stem cell function and Nrf2. Biochemical Society Transactions, Biochem. Soc. Trans. (2015) 43, 627–631
  • Madhavan L. Chapter on Neural Stem Cells for Intrinsic Brain Repair in Aging and Neural Degeneration. Book Title: “Neural Stem Cells in Health and Disease”, World Scientific Publishing Company, Singapore. http://www.worldscientific.com/worldscibooks/10.1142/9309