Kristian Doyle, PhD

Kristian Doyle, PhD

Associate Professor
Associate Professor, Immunobiology
Associate Professor, Neurology
Associate Professor, Psychology
Associate Professor, BIO5 Institute
Associate Professor, Neurosurgery
Associate Professor, Neuroscience-GIDP
Research Scientist, Arizona Center on Aging

Contact:

University of Arizona
Medical Research Bldg, Rm 214
Department of Immunobiology
1656 E Mabel St
Tucson, AZ 85724
(520) 626-7013
doylekr@arizona.edu

Dr. Kristian Doyle is an Associate Professor in the Department of Immunobiology, with a secondary appointment in Neurology at the University of Arizona. He earned his Bachelor’s degree from the University of Sussex, his Ph.D. from Oregon Health & Science University—where he developed novel stroke therapies under Dr. Mary Stenzel-Poore—and completed postdoctoral training at Stanford University, researching TGF-beta signaling and post-stroke dementia with Dr. Marion Buckwalter. Since founding his lab at the University of Arizona in 2013, Dr. Doyle has focused on stroke immunology, specifically the role of chronic inflammation in post-stroke recovery. His research aims to develop therapeutic strategies to improve quality of life for stroke survivors. Dr. Doyle’s work has been recognized by numerous awards, including an American Federation of Aging Research Fellowship, the Anita Roberts Young Scientist Scholarship, and a K99/R00 faculty transition award from the National Institute of Nursing Research.

The Doyle Lab

Education

Degrees: 
PhD: 2007, Oregon Health & Science University, Portland, OR
BS: University of Sussex
Fellowship: 
Standard University

Selected Publications

  • Zbesko, J. C., J. Stokes, D. A. Becktel, and K. P. Doyle, "Targeting foam cell formation to improve recovery from ischemic stroke.", Neurobiol Dis, vol. 181, pp. 106130, 2023 Jun 01. PMID: 37068641
  • Loppi, S. H., M. A. Tavera-Garcia, D. A. Becktel, B. K. Maiyo, K. E. Johnson, T-V. V. Nguyen, R. G. Schnellmann, and K. P. Doyle, "Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke.", J Cereb Blood Flow Metab, vol. 43, issue 7, pp. 1099-1114, 2023 Jul. PMCID: PMC10291449  PMID: 36772984
  • Loppi, S. H., M. A. Tavera-Garcia, N. E. Scholpa, B. K. Maiyo, D. A. Becktel, H. W. Morrison, R. G. Schnellmann, and K. P. Doyle, "Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain.", Int J Mol Sci, vol. 24, issue 23, 2023 Nov 23. PMCID: PMC10706318  PMID: 38068955
  • Pederson, W. P., L. M. Ellerman, E. C. Sandoval, S. Boitano, J. B. Frye, K. P. Doyle, H. L. Brooks, F. Polverino, and J. G. Ledford, "Development of a Novel Mouse Model of Menopause-associated Asthma.", Am J Respir Cell Mol Biol, vol. 67, issue 5, pp. 605-609, 2022 Nov. PMCID: PMC9651199  PMID: 36318015
  • Dwyer, L. J., A. M. Stowe, K. Doyle, P. Popovich, E. Engler-Chiurazzi, C. LeGuern, M. S. Buckwalter, M. C. Poznansky, and R. F. Sîrbulescu, "The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022.", FASEB J, vol. 36, issue 8, pp. e22459, 2022 Aug. PMCID: PMC9337863  PMID: 35857314
  • Becktel, D. A., J. C. Zbesko, J. B. Frye, A. G. Chung, M. Hayes, K. Calderon, J. W. Grover, A. Li, F. G. Garcia, M. A. Tavera-Garcia, et al., "Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke", Journal of Neuroscience, vol. Jan 42; 2: 325-348, 2022.
  • Nguyen, T. V., R. H. Crumpacker, K. E. Calderon, F. G. Garcia, J. C. Zbesko, J. B. Frye, S. Gonzalez, D. A. Becktel, T. Yang, M. A. Tavera-Garcia, et al., "Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery", Journal of Pharmacology and experimental Therapeutics, vol. JPET-AR-2021-000711, 2021.
  • Zbesko, J.C., J.B. Frye, D.A. Becktel, D.K. Gerardo, J. Stokes, K. Calderon, T.V. Nguyen, D. Bhattacharya, and K.P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke", Brain Behavior and Immunity, vol. 91, 2021.
  • Hoyer-Kimura, C., J.P. Konhilas, H.M. Mansour, R. Polt, K.P. Doyle, D. Billheimer, and M. Hay, "Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia.", Journal of Neuroinflammation, vol. 18(1), 10/2021.
  • Zbesko, J. C., J. Beischel Frye, D. A. Becktel, D. K. Gerardo, J. Stokes, K. Calderon, T-V. V. Nguyen, D. Bhattacharya, and K. P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke.", Brain Behav Immun, 2020 Sep 18. PMID: 32956832