Kristian Doyle, PhD

Associate Professor

Contact:

University of Arizona
Medical Research Bldg, Rm 214
Department of Immunobiology
1656 E Mabel St
Tucson, AZ 85724
(520) 626-7013

Dr. Kristian Doyle is an Associate Professor in the Department of Immunobiology with a secondary appointment in the Department of Neurology. He earned his Bachelor's degree from the University of Sussex in the UK, his PhD from Oregon Health & Science University, and completed postdoctoral training at Stanford University. Since establishing his lab at the University of Arizona in 2013, Dr. Doyle has focused on stroke immunology, particularly the mechanisms of chronic inflammation post-stroke and its impact on recovery. The goal of his lab is to develop novel therapeutic strategies that improve quality of life in stroke survivors. The Doyle Lab

Education

Degrees: 
PhD: Oregon Health & Science University, Portland, OR

Selected Publications

  • Cekanaviciute E, Fathali N, Doyle KP, Williams AM, Han J, Buckwalter MS. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. 2014;62:1227–1240.
  • Doyle KP, Buckwalter MS. A mouse model of permanent focal ischemia: distal middle cerebral artery occlusion. Methods Mol. Biol. Clifton NJ. 2014;1135:103–110.
  • Pollak J, Doyle KP, Mamer L, Shamloo M, Buckwalter MS. Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model. Brain Behav. 2012;2:698–706.
  • Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS. Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke. Stroke J. Cereb. Circ. 2012;43:1918–1924.
  • Doyle KP, Buckwalter MS. The double-edged sword of inflammation after stroke: what sharpens each edge? Ann. Neurol. 2012;71:729–731.
  • Doyle KP, Fathali N, Siddiqui MR, Buckwalter MS. Distal hypoxic stroke: a new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit. J. Neurosci. Methods. 2012;207:31–40.
  • Bahjat FR, Williams-Karnesky RL, Kohama SG, West GA, Doyle KP, Spector MD, Hobbs TR, Stenzel-Poore MP. Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke. J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab. 2011;31:1229–1242.
  • Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS. TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J. Neuroinflammation. 2010;7:62.
  • West GA, Golshani KJ, Doyle KP, Lessov NS, Hobbs TR, Kohama SG, Pike MM, Kroenke CD, Grafe MR, Spector MD, Tobar ET, Simon RP, Stenzel-Poore MP. A new model of cortical stroke in the rhesus macaque. J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab. 2009;29:1175–1186.
  • Doyle KP, Simon RP, Stenzel-Poore MP. Mechanisms of ischemic brain damage. Neuropharmacology. 2008;55:310–318.