Carol Barnes, PhD

Professor
Director, Division of Neural Systems, Memory and Aging
Director, Evelyn F Mcknight Brain Institute

Contact:

Life Sciences North 355
Department of Psychology
(520) 626-2616

Carol A. Barnes is a Regents Professor in the Departments of Psychology, Neurology, and Neuroscience at the University of Arizona, holding the Evelyn F. McKnight Endowed Chair for Learning and Memory in Aging. She also serves as Director of the Evelyn F. McKnight Brain Institute and the Division of Neural Systems, Memory, and Aging. A prominent figure in neuroscience, Dr. Barnes is a past-president of the Society for Neuroscience, a Fellow of the American Association for the Advancement of Science, an elected member of the National Academy of Sciences, and a Foreign Member of the Royal Norwegian Society of Sciences and Letters. Her numerous accolades include the 2013 Gerard Prize in Neuroscience and the 2014 APA Award for Distinguished Scientific Contributions.

Dr. Barnes’ research focuses on understanding the brain’s changes during normative aging and their functional implications for memory. Her work spans behavioral, electrophysiological, and molecular biological approaches, studying young and aged rodents, non-human primates, and, more recently, humans through the Precision Aging Network. This program aims to enhance cognitive health across the lifespan, and her findings, with over 285 published works (H-index of 112), are considered foundational in brain aging and behavior.

Over the past four decades, Dr. Barnes has examined the mechanisms of cognitive aging using animal models that provide insight into the brain circuits underlying learning, memory, and complex cognitive function. Integrating behavioral, anatomical, electrophysiological, and molecular approaches, her work aspires to unlock how brain function changes across the lifespan, with the ultimate hope of positively influencing cognitive aging trajectories.

Education

Degrees: 
PhD: Psychology, Carleton University, Ottawa, Ontario, Canada
MA: Psychology, Carleton University, Ottawa, Ontario, Canada
BA: Psychology, University of California, Riverside, California, U.S.A.

Selected Publications

  • Hill, P. F., Bermudez, S., McAvan, A. S., Garren, J. D., Grilli, M. D., Barnes, C. A., & Ekstrom, A. D. (2024). Age differences in spatial memory are mitigated during naturalistic navigation. Aging, Neuropsychology, and Cognition, 1–25. https://doi.org/10.1080/13825585.2024.2326244
  • Zheng, L., Gao, Z., Doner, S., Oyao, A., Forloines, M., Grilli, M. D., Barnes, C. A., & Ekstrom, A. D. (2023). Hippocampal contributions to novel spatial learning are both age-related and age-invariant. Proceedings of the National Academy of Sciences of the United States of America, 120(50), e2307884120. https://doi.org/10.1073/pnas.2307884120
  • Gray, D. T., Zempare, M., Carey, N., Khattab, S., Sinakevitch, I., De Biase, L. M., & Barnes, C. A. (2023). Extracellular matrix proteoglycans support aged hippocampus networks: a potential cellular-level mechanism of brain reserve. Neurobiology of aging, 131, 52–58. https://doi.org/10.1016/j.neurobiolaging.2023.07.010
  • Sinakevitch, Irina & Mcdermott, Kelsey & Gray, Daniel & Barnes, Carol. (2023). A HIGH-RESOLUTION 3D RECONSTRUCTION OF THE LOCUS COERULEUS IN ADULT AND AGED RHESUS MACAQUES. IBRO Neuroscience Reports. 15. S499-S500. 10.1016/j.ibneur.2023.08.978.
  • Zheng, L., Gao, Z., Doner, S., Oyao, A., Forloines, M., Grilli, M., ... & Ekstrom, A. D. (2023). Age-related spatial memory differences are correlated with neural remapping in CA1 of the human hippocampus. Biorxiv: the Preprint Server for Biology.
  • Gray, D. T., Khattab, S., Meltzer, J., McDermott, K., Schwyhart, R., Sinakevitch, I., Härtig, W., & Barnes, C. A. (2023). Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques. Cerebral cortex (New York, N.Y. : 1991), 33(8), 4626–4644. https://doi.org/10.1093/cercor/bhac366
  • Stern, Y., Albert, M., Barnes, C. A., Cabeza, R., Pascual-Leone, A., & Rapp, P. R. (2023). A framework for concepts of reserve and resilience in aging. Neurobiology of aging, 124, 100–103. https://doi.org/10.1016/j.neurobiolaging.2022.10.015
  • Lester, A. W., Jordan, G. A., Blum, C. J., Philpot, Z. P., & Barnes, C. A. (2022). Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues. Behavioral neuroscience, 136(6), 561–574. https://doi.org/10.1037/bne0000536
  • Crown, L. M., Gray, D. T., Schimanski, L. A., Barnes, C. A., & Cowen, S. L. (2022). Aged Rats Exhibit Altered Behavior-Induced Oscillatory Activity, Place Cell Firing Rates, and Spatial Information Content in the CA1 Region of the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(22), 4505–4516. https://doi.org/10.1523/JNEUROSCI.1855-21.2022