Drug Discovery – Current Trends and Future Prospects

Jan 16, 2019

Drug Discovery – Current Trends and Future Prospects

Saturday, February 23rd, 2019
BIO5 Institute, Thomas W. Keating Bioresearch Building, Room 103
University of Arizona, Tucson

9:00-9:10 Introduction
Gerry Maggiora (Organizer), BIO5 Institute, Tucson, AZ

9:10-9:40 Phenotype-based drug discovery: a view through the lens of genetics
Linda Restifo, University of Arizona Health Sciences, Tucson, AZ

9:40-10:10 Mechanistically informed discovery of targeted cancer therapy
Karen Lackey, University of Arizona, Tucson, AZ; Centaur Biosciences, Charleston, SC

10:10-10:40 “Direct to drug” screening – a novel approach to individualized therapy in
multiple myeloma
Nathalie Meurice, Mayo Clinic, Scottsdale, AZ

10:40-10:55 BREAK

10:55-11:25 Target ID: the final frontier
Christian Parker, Novartis, Basel, Switzerland

11:25-11:55 Using machine learning (not “AI”) to prioritize novel targets
Tudor Oprea, University of New Mexico, Albuquerque, New Mexico

11:55-12:25 Docking 250 million molecules for ligand discovery
Brian Shoichet, University of California, San Francisco, CA

12:25-1:20 LUNCH

1:20-1:50 Hit diffusion – where are all the good screening hits?
John van Drie, Van Drie Research LLC, Cambridge, MA

1:50-2:20 Why do drugs have the affinities they have?
Jordi Mestres, IMIM Hospital del Mar Medical Research Institute, Barcelona, Catalonia, Spain

2:20-2:50 Protein motion as a tool for drug discovery
Pat Walters, Relay Therapeutics, Cambridge, MA

2:50-3:20 Chemoinformatics: a perspective from an academic setting in Latin America
Jose Medina-Franco, Universidad Nacional Autónoma de México, Mexico City, Mexico